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. 2011 Jan 21;6(1):e16317.
doi: 10.1371/journal.pone.0016317.

Polymorphic allele of human IRGM1 is associated with susceptibility to tuberculosis in African Americans

Katherine Y King  1 , Justin D Lew, Ngan P Ha, Jeffery S Lin, Xin Ma, Edward A Graviss, Margaret A Goodell
Affiliations

Polymorphic allele of human IRGM1 is associated with susceptibility to tuberculosis in African Americans

Katherine Y King et al. PLoS One. .

Abstract

An ancestral polymorphic allele of the human autophagy-related gene IRGM1 is associated with altered gene expression and a genetic risk for Crohn's Disease (CD). We used the single nucleotide polymorphism rs10065172C/T as a marker of this polymorphic allele and genotyped 370 African American and 177 Caucasian tuberculosis (TB) cases and 180 African American and 110 Caucasian controls. Among African Americans, the TB cases were more likely to carry the CD-related T allele of rs10065172 (odds ratio of 1.54; 95% confidence interval, 1.17-2.02; P<0.01) compared to controls. Our finding suggests that this CD-related IRGM1 polymorphic allele is also associated with human susceptibility to TB disease among African Americans.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. The risk allele frequency for SNP rs10065172 is higher among African Americans with TB disease compared to unaffected controls.
For each group the bar and n are as follows: Caucasian controls (white) n = 110; Caucasian cases (white stripes) n = 177; African American controls (grey) n = 180; African American cases (grey stripes) n = 370. Differences (***) are significant (P<0.001) by chi-squared test.
See this image and copyright information in PMC

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