Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2011 Jan 27;9 Suppl 1(Suppl 1):S7.
doi: 10.1186/1479-5876-9-S1-S7.

Coreceptor use in nonhuman primate models of HIV infection

Silvana Tasca Sina  1 , Wuze Ren, Cecilia Cheng-Mayer
Affiliations
Review

Coreceptor use in nonhuman primate models of HIV infection

Silvana Tasca Sina et al. J Transl Med. .

Abstract

SIV or SHIV infection of nonhuman primates (NHP) has been used to investigate the impact of coreceptor usage on the composition and dynamics of the CD4+ T cell compartment, mechanisms of disease induction and development of clinical syndrome. As the entire course of infection can be followed, with frequent access to tissue compartments, infection of rhesus macaques with CCR5-tropic SHIVs further allows for study of HIV-1 coreceptor switch after intravenous and mucosal inoculation, with longitudinal and systemic analysis to determine the timing, anatomical sites and cause for the change in envelope glycoprotein and coreceptor preference. Here, we review our current understanding of coreceptor use in NHPs and their impact on the pathobiological characteristics of the infection, and discuss recent advances in NHP studies to uncover the underlying selective pressures for the change in coreceptor preference in vivo.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Gardner MB, Luciw PA. Animal models of AIDS. FASEB J. 1989;3:2593–2606. - PubMed
    1. Alter HJ, Eichberg JW, Masur H, Saxinger WC, Gallo R, Macher AM, Lane HC, Fauci AS. Transmission of HTLV-III infection from human plasma to chimpanzees: an animal model for AIDS. Science. 1984;226:549–552. doi: 10.1126/science.6093251. - DOI - PubMed
    1. Lusso P, Markham PD, Ranki A, Earl P, Moss B, Dorner F, Gallo RC, Krohn KJ. Cell-mediated immune response toward viral envelope and core antigens in gibbon apes (Hylobates lar) chronically infected with human immunodeficiency virus-1. J Immunol. 1988;141:2467–2473. - PubMed
    1. Davis IC, Girard M, Fultz PN. Loss of CD4+ T cells in human immunodeficiency virus type 1-infected chimpanzees is associated with increased lymphocyte apoptosis. J Virol. 1998;72:4623–4632. - PMC - PubMed
    1. Novembre FJ, de Rosayro J, Nidtha S, O'Neil SP, Gibson TR, Evans-Strickfaden T, Hart CE, McClure HM. Rapid CD4(+) T-cell loss induced by human immunodeficiency virus type 1(NC) in uninfected and previously infected chimpanzees. J Virol. 2001;75:1533–1539. doi: 10.1128/JVI.75.3.1533-1539.2001. - DOI - PMC - PubMed

Substances