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Meta-Analysis
. 2011 Feb;204(2):134.e1-20.
doi: 10.1016/j.ajog.2010.11.038.

Nifedipine in the management of preterm labor: a systematic review and metaanalysis

Agustín Conde-Agudelo  1 , Roberto Romero, Juan Pedro Kusanovic
Affiliations
Meta-Analysis

Nifedipine in the management of preterm labor: a systematic review and metaanalysis

Agustín Conde-Agudelo et al. Am J Obstet Gynecol. 2011 Feb.

Abstract

Objective: To determine the efficacy and safety of nifedipine as a tocolytic agent in women with preterm labor.

Study design: A systematic review and metaanalysis of randomized controlled trials.

Results: Twenty-six trials (2179 women) were included. Nifedipine was associated with a significant reduction in the risk of delivery within 7 days of initiation of treatment and before 34 weeks' gestation, respiratory distress syndrome, necrotizing enterocolitis, intraventricular hemorrhage, neonatal jaundice, and admission to the neonatal intensive care unit when compared with β₂-adrenergic-receptor agonists. There was no difference between nifedipine and magnesium sulfate in tocolytic efficacy. Nifedipine was associated with significantly fewer maternal adverse events than β₂-adrenergic-receptor agonists and magnesium sulfate. Maintenance nifedipine tocolysis was ineffective in prolonging gestation or improving neonatal outcomes when compared with placebo or no treatment.

Conclusion: Nifedipine is superior to β₂-adrenergic-receptor agonists and magnesium sulfate for tocolysis in women with preterm labor.

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