You are what your dad ate
- PMID: 21284975
- DOI: 10.1016/j.cmet.2011.01.011
You are what your dad ate
Abstract
Maternal nutrition and metabolism are critical determinants of adult offspring health. Recent reports describe adverse offspring outcomes associated with the father's diet, indicating nongenetic inheritance of paternal experience. Determining underlying mechanisms may require reconsideration of our understanding of the heritability of epigenetic states.
Copyright © 2011 Elsevier Inc. All rights reserved.
Comment on
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Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring.Nature. 2010 Oct 21;467(7318):963-6. doi: 10.1038/nature09491. Nature. 2010. PMID: 20962845
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Paternally induced transgenerational environmental reprogramming of metabolic gene expression in mammals.Cell. 2010 Dec 23;143(7):1084-96. doi: 10.1016/j.cell.2010.12.008. Cell. 2010. PMID: 21183072 Free PMC article.
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