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Multicenter Study
. 2011 Feb;26(2):174-83.
doi: 10.3346/jkms.2011.26.2.174. Epub 2011 Jan 24.

Etiology of invasive bacterial infections in immunocompetent children in Korea (1996-2005): a retrospective multicenter study

Joon-Ho Lee  1 , Hye Kyung Cho, Kyung-Hyo Kim, Chang Hwi Kim, Dong Soo Kim, Kwang Nam Kim, Sung-Ho Cha, Sung Hee Oh, Jae Kyun Hur, Jin Han Kang, Jong Hyun Kim, Yun-Kyung Kim, Young Jin Hong, Eun Hee Chung, Soo-Eun Park, Young Youn Choi, Jung Soo Kim, Hwang Min Kim, Eun Hwa Choi, Hoan Jong Lee
Affiliations
Multicenter Study

Etiology of invasive bacterial infections in immunocompetent children in Korea (1996-2005): a retrospective multicenter study

Joon-Ho Lee et al. J Korean Med Sci. 2011 Feb.

Abstract

The purpose of this study was to identify the major etiological agents responsible for invasive bacterial infections in immunocompetent Korean children. We retrospectively surveyed invasive bacterial infections in immunocompetent children caused by eight major pediatric bacteria, namely Streptococcus pneumoniae, Haemophilus influenzae, Neisseria meningitidis, Staphylococcus aureus, Streptococcus agalactiae, Streptococcus pyogenes, Listeria monocytogenes, and Salmonella species that were diagnosed at 18 university hospitals from 1996 to 2005. A total of 768 cases were identified. S. agalactiae (48.1%) and S. aureus (37.2%) were the most common pathogens in infants younger than 3 months. S. agalactiae was a common cause of meningitis (73.0%), bacteremia without localization (34.0%), and arthritis (50%) in this age group. S. pneumoniae (45.3%) and H. influenzae (20.4%) were common in children aged 3 months to 5 yr. S. pneumoniae was a common cause of meningitis (41.6%), bacteremia without localization (40.0%), and bacteremic pneumonia (74.1%) in this age group. S. aureus (50.6%), Salmonella species (16.9%), and S. pneumoniae (16.3%) were common in older children. A significant decline in H. influenzae infections over the last 10 yr was noted. S. agalactiae, S. pneumoniae, and S. aureus are important pathogens responsible for invasive bacterial infections in Korean children.

Keywords: Bacteremia; Bacterial Infections; Epidemiology; Meningitis; Staphylococcus aureus; Streptococcus agalactiae; Streptococcus pneumonia.

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Figures

Fig. 1
Fig. 1
Distribution of causative bacterial organisms in invasive infections in immunocompetent Korean children between 1996 and 2005 according to age group and clinical spectrum.
Fig. 2
Fig. 2
Temporal changes in the relative proportions of the four most prevalent causative bacterial organisms of invasive infections in immunocompetent Korean children 3 months of age or older between 1996 and 2005.
See this image and copyright information in PMC

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