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. 2011 Apr;22(4):529-40.
doi: 10.1007/s10552-011-9729-4. Epub 2011 Feb 1.

Estrogens in the breast tissue: a systematic review

Lusine Yaghjyan  1 , Graham A Colditz
Affiliations

Estrogens in the breast tissue: a systematic review

Lusine Yaghjyan et al. Cancer Causes Control. 2011 Apr.

Abstract

The role of estrogens in breast carcinogenesis has been investigated at the level of whole body (plasma) and cell (molecular, receptors, etc.). Growing attention focused on the breast tissue being an intracrine organ, with potentially important local estrogen production in the breast. However, very little is known about the local breast tissue estrogen levels. Understanding the role of the tissue estrogens in breast carcinogenesis might open new avenues in breast cancer prevention. This systematic review summarizes published studies that measured local estrogen levels in the breast and offers suggestions for strategies to fill gaps in our existing scientific knowledge.

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Conflict of interest statement

Conflict of interests The authors declare that they have no conflict of interests.

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