Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011 Apr;49(4):1621-3.
doi: 10.1128/JCM.02214-10. Epub 2011 Feb 2.

Evaluation of the Cepheid Xpert MTB/RIF assay for direct detection of Mycobacterium tuberculosis complex in respiratory specimens

Elizabeth M Marlowe  1 , Susan M Novak-Weekley, Joven Cumpio, Susan E Sharp, Michelle A Momeny, Anna Babst, Jonathan S Carlson, Masae Kawamura, Mark Pandori
Affiliations

Evaluation of the Cepheid Xpert MTB/RIF assay for direct detection of Mycobacterium tuberculosis complex in respiratory specimens

Elizabeth M Marlowe et al. J Clin Microbiol. 2011 Apr.

Abstract

A total of 217 specimens submitted for routine smear and culture from three different sites within the western United States were used to evaluate the GeneXpert MTB/RIF assay (for research use only) (Cepheid, Sunnyvale, CA). Overall agreement compared to culture was 89% (98% for smear positives and 72% for smear negatives) for detection of Mycobacterium tuberculosis.

PubMed Disclaimer

References

    1. American Thoracic Society 2000. Diagnostic standards and classification of tuberculosis in adults and children. Am. J. Respir. Crit. Care Med. 161:1376–1395 - PubMed
    1. Ashok R., Awdhesh K., Nishat A. 1998. Mulitdrug-resistant Mycobacterium tuberculosis: molecular perspectives. Emerg. Infect. Dis. 4:195–209 - PMC - PubMed
    1. Blakemore R., et al. 2010. Evaluation of the analytical performance of the Xpert MTB/RIF assay. J. Clin. Microbiol. 48:2495–2501 - PMC - PubMed
    1. Boehme C. C., et al. 2010. Rapid molecular detection of tuberculosis and rifampin resistance. N. Engl. J. Med. 363:1005–1015 - PMC - PubMed
    1. Brown S., et al. 2010. Direct detection of Mycobacterium tuberculosis and rifampin resistance in respiratory specimens using realtime PCR with the GeneXpert MTB/RIF, abstr. C-157. Abstr. 110th Gen. Meet. Am. Soc. Microbiol American Society for Microbiology, Washington, DC

Publication types

MeSH terms

LinkOut - more resources