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Review
. 2011 Mar;28(3):543-93.
doi: 10.1039/c0np00059k. Epub 2011 Feb 2.

Synthesis, biology and clinical significance of pentacyclic triterpenes: a multi-target approach to prevention and treatment of metabolic and vascular diseases

Huaming Sheng  1 , Hongbin Sun
Affiliations
Review

Synthesis, biology and clinical significance of pentacyclic triterpenes: a multi-target approach to prevention and treatment of metabolic and vascular diseases

Huaming Sheng et al. Nat Prod Rep. 2011 Mar.

Abstract

This review (with 335 references cited) is devoted to pentacyclic triterpenes. The total synthesis, semi-synthesis, structural modification, and metabolic behavior of naturally occurring pentacyclic triterpenes are described. We also cover the in vivo evidence, mechanistic studies, and clinical significance of pentacyclic triterpenes as multi-target therapeutic agents for the prevention and treatment of metabolic and vascular diseases.

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