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Case Reports
. 2011 Jul;258(7):1351-3.
doi: 10.1007/s00415-011-5917-0. Epub 2011 Feb 3.

Anti-N-methyl-D-aspartate receptor encephalitis associated with carcinosarcoma with neuroendocrine differentiation of the uterus

Makoto Hara, Akihiko Morita, Satoshi Kamei, Mai Yamaguchi, Taku Homma, Norimichi Nemoto, Kenji Sugita, Tatsuo Yamamoto, Josep Dalmau
Case Reports

Anti-N-methyl-D-aspartate receptor encephalitis associated with carcinosarcoma with neuroendocrine differentiation of the uterus

Makoto Hara et al. J Neurol. 2011 Jul.
No abstract available

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Figures

Fig. 1
Fig. 1
Cranial MRI (a–c). Abnormalities of high intensity in both, predominantly in the left, limbic area, mainly hippocampus and amygdala, were revealed on FLAIR (a) and diffusion images (b), whereas gadolinium-enhanced T1-weighted image (c) shown no abnormality in these areas. Microscopic findings for the removed tumor (d–i). On hematoxylin–eosin staining, solid nests of viable atypical cells with frequent mitoses and marked venous/lymphatic infiltration were observed in the uterine tumor, though it exhibited extensive necrosis (d). On immunohistochemical examination, most of this tumor was frequently positive for synaptophysin (e), CD56 (f), and neuron-specific enolase (g). Chromogranin immunoreactivity was also noted in the tumor (h). Based on these findings, the tumor was diagnosed as a carcinosarcoma with neuroendocrine differentiation of the uterus. The tumor expressed ectopic NR1 subunits of NMDAR, as determined using a monoclonal antibody to mouse IgG. The tumor also exhibited membranous NR1 staining (i). All scale bars are 50 μm, with original magnification ×400
See this image and copyright information in PMC

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