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Review

Vaccines

Jacques Pappo  1 , Steven Czinn  2 , John Nedrud  3
Harry LT Mobley  1 , George L Mendz  2 , Stuart L Hazell  3
, editors.
In: Helicobacter pylori: Physiology and Genetics. Washington (DC): ASM Press; 2001. Chapter 37.
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Review

Vaccines

Jacques Pappo et al.
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Excerpt

The immune response to H. pylori is remarkably diverse. Evidence from human and animal studies has shown that the immune system expends substantial energy in response to H. pylori. Yet, the infection is commonly lifelong, and the immune response activated against this organism does not effect clearance or prevent reinfection after successful antimicrobial treatment (131). The immune functions in cases of spontaneous "clearance" in pediatric populations (92, 109) or in animal models (37) are unknown. However, mathematical (16) and animal (38) infection models describe a central role for the host response in the regulation of H. pylori load throughout the course of the infection, and thus, predict that shifts in the host response can affect the dynamics of this host-microbial equilibrium.

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References

    1. Agren L. C., Ekman L., Lowenadler B., Nedrud J. G., Lycke N. Y. Adjuvanticity of the cholera toxin A1-based gene fusion protein, CTA1-DD, is critically dependent on the ADP-ribosyltransferase and Ig-binding activity. J. Immunol. 1999;162:2432–2440. - PubMed
    1. Ahlstedt I., Lindholm C., Lonroth H., Hamlet A., Svennerholm A. M., Quiding-Jarbrink M. Role of local cytokines in increased gastric expression of the secretory component in Helicobacter pylori infection. Infect. Immun. 1999;67:4921–4925. - PMC - PubMed
    1. Alm R. A., Ling L.-S. L., Moir D. T., King B. L., Brown E. D., Doig P. C., Smith D. R., Noonan B., Guild B. C., deJonge B. L., Carmel G., Tummino P. J., Caruso A., Uria-Nickelsen M., Mills D. M., Ives C., Gibson R., Merberg D., Mills S. D., Jiang Q., Taylor D. E., Vovis G. F., Trust T. J. Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori. Nature. 1999;397:176–180. - PubMed
    1. Angelakopoulos H., Hohmann E. L. Pilot study of phoP/phoQ-deleted Salmonella enterica serovar Typhimurium expressing Helicobacter pylori urease in adult volunteers. Infect. Immun. 2000;68:2135–2141. - PMC - PubMed
    1. Appelmelk B. J., Martin S. L., Monteiro M. A., Clayton C. A., McColm A. A., Zheng P., Verboom T., Maaskant J. J., van den Eijnden D. H., Hokke C. H., Perry M. B., Vandenbroucke-Grauls C. M. J. E., Kusters J. G. Phase variation in Helicobacter pylori lipopolysaccharide due to changes in the lengths of poly(C) tracts in α3-fucosyltransferase genes. Infect. Immun. 1999;67:5361–5366. - PMC - PubMed

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