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Review

In Vivo Adaptation to the Host

Richard L. Ferrero  1 , Peter J. Jenks  2
Harry LT Mobley  1 , George L Mendz  2 , Stuart L Hazell  3
, editors.
In: Helicobacter pylori: Physiology and Genetics. Washington (DC): ASM Press; 2001. Chapter 46.
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Review

In Vivo Adaptation to the Host

Richard L. Ferrero et al.
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Excerpt

Colonization of the human gastric mucosa by H. pylori occurs as a result of a dynamic interactive process between the pathogen and its host. While many of the bacterial mechanisms involved in this adaptation are beginning to be elucidated, little is known of the changes that occur in the host during the initiation and establishment of infection by H. pylori. The availability of the human genome sequence and cDNA array/differential display technologies permitting the simultaneous analysis of the expression of thousands of host genes in response to an infection (18), as well as the development of novel transgenic and knockout mouse models, should allow a better understanding of the contribution of host factors to microbial pathogenesis.

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