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Review

Role of Stretch-activated Channels in the Heart: Action Potential and Ca2+ Transients

Jae Boum Youm  1 , Jin Han  1 , Nari Kim  1 , Yin-Hua Zhang  2 , Euiyong Kim  1 , Chae Hun Leem  3 , Sung Joon Kim  4 , Yung E. Earm  4
Andre Kamkin, Irina Kiseleva
, editors.
In: Mechanosensitivity in Cells and Tissues. Moscow: Academia; 2005.
[updated ].
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Review

Role of Stretch-activated Channels in the Heart: Action Potential and Ca2+ Transients

Jae Boum Youm et al.
Free Books & Documents

Excerpt

The heart contraction is preceded by the excitation of cardiomyocytes. Conversely, a myocardial contraction can modulate the excitation of cardiomycytes by alteration of the action potential and Ca2+ transients. This modulation is generally referred to as a mechano-electric feedback. Stretch-activated channels have been suggested as a possible mechano-transducer of the mechano-electric feedback. The channel properties such as ionic selectivity, voltage-dependence and stretch-dependence have been studied on the channel to clarify its roles in the generation of stretch-induced changes in electrical activity and Ca2+ transients. In spite of technical difficulty and some contradictory results between investigators, there are increasing evidences convincing the stretch-activated channel as the mechano-transducer of the mechano-electric feedback. We will discuss recent progress in this issue and some simulation results will be presented here to demonstrate the role of stretch-activated channels based on the experimental findings from the rat atrial myocytes.

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References

    1. Allen DG, Kentish JC. Calcium concentration in the myoplasm of skinned ferret ventricular muscle following changes in muscle length. J Physiol. (1988);407:489–503. - PMC - PubMed
    1. Allen DG, Kurihara S. The effects of muscle length on intracellular calcium transients in mammalian cardiac muscle. J Physiol. (1982);327:79–94. - PMC - PubMed
    1. Alvarez BV, Perez NG, Ennis IL, Camilion de Hurtado MC, Cingolani HE. Mechanisms underlying the increase in force and Ca2+ transient that follow stretch of cardiac muscle: a possible explanation of the Anrep effect. Circ Res. (1999);85(8):716–722. - PubMed
    1. Baartscheer A, Schumacher CA, van Borren MM, Belterman CN, Coronel R, Fiolet JW. Increased Na+/H+-exchange activity is the cause of increased [Na+]i and underlies disturbed calcium handling in the rabbit pressure and volume overload heart failure model. Cardiovasc Res. (2003);57(4):1015–1024. - PubMed
    1. Banes AJ, Gilbert J, Taylor D, Monbureau O. A new vacuum-operated stress-providing instrument that applies static or variable duration cyclic tension or compression to cells in vitro. J Cell Sci. (1985);75:35–42. - PubMed

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