Nasopharyngeal carriage of Neisseria meningitidis in general population and meningococcal disease

Abstract

Nasopharyngeal carriage of Neisseria meningitidis was determined in the normal healthy population in Delhi at monthly intervals for a period of 2 years from January, 1986 to December, 1987. Of a total of 6513 individuals screened only 107 (1.64 per cent) were found to carry Neisseria meningitidis serogroup A. There was no age and sex difference in carriage. During the same period, data of laboratory confirmed cases of meningitis due to N. meningitidis serogroup A was obtained from 6 hospitals of Delhi which acted as sentinel centres. Of the total 11,870 pyogenic C.S.F. samples processed, only 557 (4.69 per cent) were due to N. meningitidis serogroup A. There was no correlation observed between the nasopharyngeal meningococcal carriage in the healthy population with the disease prevalence. There was no seasonal variation in nasopharyngeal carriage though upsurge in the number of meningococcal meningitis cases was noticed from January to April.