Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011 Feb;17(2):255-7.
doi: 10.3201/eid1702.101724.

Characteristics of patients with oseltamivir-resistant pandemic (H1N1) 2009, United States

Samuel B Graitcer  1 , Larisa Gubareva, Laurie Kamimoto, Saumil Doshi, Meredith Vandermeer, Janice Louie, Christine Waters, Zack Moore, Katrina Sleeman, Margaret Okomo-Adhiambo, Steven A Marshall, Kirsten St George, Chao Yang Pan, Jennifer M LaPlante, Alexander Klimov, Alicia M Fry
Affiliations

Characteristics of patients with oseltamivir-resistant pandemic (H1N1) 2009, United States

Samuel B Graitcer et al. Emerg Infect Dis. 2011 Feb.

Abstract

During April 2009-June 2010, thirty-seven (0.5%) of 6,740 pandemic (H1N1) 2009 viruses submitted to a US surveillance system were oseltamivir resistant. Most patients with oseltamivir-resistant infections were severely immunocompromised (76%) and had received oseltamivir before specimen collection (89%). No evidence was found for community circulation of resistant viruses; only 4 (unlinked) patients had no oseltamivir exposure.

PubMed Disclaimer

References

    1. Deyde VM, Okomo-Adhiambo M, Sheu TG, Wallis TR, Fry A, Dharan N, et al. Pyrosequencing as a tool to detect molecular markers of resistance to neuraminidase inhibitors in seasonal influenza A viruses. Antiviral Res. 2009;81:16–24. 10.1016/j.antiviral.2008.08.008 - DOI - PubMed
    1. Sheu TG, Deyde VM, Okomo-Adhiambo M, Garten RJ, Xu X, Bright RA, et al. Surveillance for neuraminidase inhibitor resistance among human influenza A and B viruses circulating worldwide from 2004 to 2008. Antimicrob Agents Chemother. 2008;52:3284–92. 10.1128/AAC.00555-08 - DOI - PMC - PubMed
    1. FluView. Nov 19, 2010. [cited 2010 Nov 19]. http://www.cdc.gov/flu/weekly/
    1. Centers for Disease Control and Prevention. Oseltamivir-resistant 2009 pandemic influenza A (H1N1) virus infection in two summer campers receiving prophylaxis—North Carolina, 2009. MMWR Morb Mortal Wkly Rep. 2009;58:969–72. - PubMed
    1. Centers for Disease Control and Prevention. Oseltamivir-resistant novel influenza A (H1N1) virus infection in two immunosuppressed patients—Seattle, Washington, 2009. MMWR Morb Mortal Wkly Rep. 2009;58:893–6. - PubMed

Publication types

MeSH terms