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Comment
. 2011 Feb 4;41(3):243-4.
doi: 10.1016/j.molcel.2011.01.016.

Ultrasensitivity and positive feedback to promote sharp mitotic entry

Youlian Goulev  1 , Gilles Charvin
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Ultrasensitivity and positive feedback to promote sharp mitotic entry

Youlian Goulev et al. Mol Cell. .
Free article

Abstract

In this issue, Trunnell et al. (2011) show that in mitotic entry the positive feedback that drives the activation of cyclin-dependent kinase (Cdk) involves a very ultrasensitive step of phosphorylation of Cdc25C by Cdk, thus strongly contributing to the switch-like behavior of this essential cell-cycle transition.

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