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Review
. 2011 Apr;15(2):335-41.
doi: 10.1016/j.cbpa.2011.01.006. Epub 2011 Feb 1.

Iron-containing transcription factors and their roles as sensors

Angela S Fleischhacker  1 , Patricia J Kiley
Affiliations
Review

Iron-containing transcription factors and their roles as sensors

Angela S Fleischhacker et al. Curr Opin Chem Biol. 2011 Apr.

Abstract

Iron-binding transcription factors are widespread throughout the bacterial world and to date are known to bind several types of cofactors, such as Fe2+, heme, or iron-sulfur clusters. The known chemistry of these cofactors is exploited by transcription factors, including Fur, FNR, and NsrR, to sense molecules such as Fe2+, gases (e.g. oxygen and nitric oxide), or reactive oxygen species. New structural data and information generated by genome-wide analysis studies have provided additional details about the mechanism and function of iron-binding transcription factors that act as sensors.

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Figures

Figure 1
Figure 1
Iron-containing transcription factors. Iron-containing transcription factors bind Fe2+, Fe-S clusters, or heme moieties and can act as sensors of various species, including metals, oxygen, oxidative stress (ox. stress), or nitric oxide (NO). Examples of these sensors are shown here and discussed in this review.
See this image and copyright information in PMC

References

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