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Clinical Trial
. 2011 Feb;84(2):270-5.
doi: 10.4269/ajtmh.2011.10-0319.

Prevention of malaria during pregnancy: assessing the effect of the distribution of IPTp through the national policy in Benin

Agnès Le Port  1 , Gilles Cottrell, Célia Dechavanne, Valérie Briand, Aziz Bouraima, José Guerra, Isabelle Choudat, Achille Massougbodji, Benjamin Fayomi, Florence Migot-Nabias, André Garcia, Michel Cot
Affiliations
Clinical Trial

Prevention of malaria during pregnancy: assessing the effect of the distribution of IPTp through the national policy in Benin

Agnès Le Port et al. Am J Trop Med Hyg. 2011 Feb.

Abstract

The efficiency of malaria prevention during pregnancy was compared between three studies in Benin for malaria infection of the placenta (MIP) and low birth weight (LBW). The first was carried out when chloroquine prophylaxis was still recommended, the second was an intermittent preventive treatment in pregnancy (IPTp) clinical trial comparing sulfadoxine pyrimetamine (SP) versus mefloquine, and the third was an observational study after SP-IPTp national implementation. We showed an association between the use of IPTp and the reduction of LBW (10% with national IPTp and 8.7% in IPTp trial versus 15.7% in pre-trial study). The effect on MIP was better in the trial (2.9% versus 11.2% and 16.7% for national IPTp and pre-trial studies, respectively). In spite of a good overall compliance with the national IPTp (with 84% of women taking at least one dose of SP), there are still failures in adherence to the directly observed therapy (DOT) scheme and needs for better training of health staff.

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Figures

Figure 1.
Figure 1.
The two study sites of Ouidah (two maternity clinics) and Tori Bossito (three maternity clinics), Benin (from Charlotte Pierrat, IRD UMR 216, Paris, France).
See this image and copyright information in PMC

References

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