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Case Reports
. 2011 Mar-Apr;31(2):197-200.
doi: 10.4103/0256-4947.76409.

Cold agglutinin disease in fibrolamellar hepatocellular carcinoma: a rare association with a rare cancer variant

Khalid Al-Matham  1 , Iehab Alabed, Syed Z A Zaidi, Khalid A Qushmaq
Affiliations
Case Reports

Cold agglutinin disease in fibrolamellar hepatocellular carcinoma: a rare association with a rare cancer variant

Khalid Al-Matham et al. Ann Saudi Med. 2011 Mar-Apr.

Abstract

Cold agglutinin disease (CAD) is a rare autoimmune hemolytic anemia. Although it can occur secondary to lymphoproliferative disorders and autoimmune or infectious diseases, CAD is rarely reported as secondary to solid tumors. We report a case of a woman aged 18 years diagnosed with a well-differentiated hepatocellular carcinoma of the fibrolamellar subtype, who was shown to have CAD also. Her general condition, including CAD, improved after targeted therapy with sorafenib for the hepatocellular carcinoma and only conservative measures for the CAD that consisted of avoidance of cold. In summary, although it is an extremely rare association and less common than lymphoproliferative disorders, CAD can be associated with solid tumors.

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Figures

Figure 1
Figure 1
CT scan of abdomen showing the hepatic tumor.
Figure 2a
Figure 2a
Liver biopsy showing hepatocellular carcinoma: fibrolamellar subtype (CK stain ×200).
Figure 2b
Figure 2b
Liver biopsy showing hepatocellular carcinoma: fibrolamellar subtype (Massionæs trichrome stain ×200).
Figure 2c
Figure 2c
Liver biopsy showing hepatocellular carcinoma: fibrolamellar subtype (Hematoxylin and eosin stain ×200).
See this image and copyright information in PMC

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