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. 2011 Apr;25(4):511-8.
doi: 10.1038/eye.2010.216. Epub 2011 Feb 4.

Comparison of retinal thickness values and segmentation performance of different OCT devices in acute branch retinal vein occlusion

G Matt  1 , S Sacu, W Buehl, C Ahlers, R Dunavoelgyi, C Pruente, U Schmidt-Erfurth
Affiliations

Comparison of retinal thickness values and segmentation performance of different OCT devices in acute branch retinal vein occlusion

G Matt et al. Eye (Lond). 2011 Apr.

Abstract

Purpose: To compare retinal thickness (RT) measurement and segmentation performance of time domain (TD, Stratus) and spectral domain (SD) optical coherence tomography (OCT) devices (Cirrus, Spectralis) for imaging macular oedema (ME) secondary to branch retinal vein occlusion (BRVO).

Methods: In this study, 20 eyes of 20 consecutive patients with acute BRVO were included. A total of 18 unaffected fellow eyes served as control group. RT measurement was analysed in the five inner fields of the early-treatment diabetic retinopathy grid, and proportional segmentation errors were evaluated.

Results: Central millimetre thickness (CMT) showed a mean difference of -64, -74, and -18 μm (P < 0.001) in the control group and -31 μm (P=0.107), -92 μm (P<0.001), and -105 μm (P=0.016) in the BRVO group, between Stratus and Cirrus, between Stratus and Spectralis, and between Cirrus and Spectralis, respectively. Mean RT showed the highest variability between different devices in the area most intensively affected by BRVO-related ME. In eyes with BRVO, 14.6% of Spectralis, 20% of Stratus, and 36.6% of Cirrus scans demonstrated moderate and severe segmentation errors.

Conclusion: RT measurement in eyes with BRVO, by TD and SD OCT, is compromised by a significant rate of segmentation errors. Deviations are most pronounced in the areas most severely affected by ME.

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Figures

Figure 1
Figure 1
Optical coherence tomography grid projection introduced by the authors of the ETDRS trial. In this study, fields within the central 3 mm diameter were evaluated. In control group, fields were named as follows: CMT, central millimetre thickness; F2, superior inner macula; F3, temporal inner macula; F4, inferior inner macula; F5, nasal inner macula. In branch retinal vein occlusion (BRVO) eyes, fields were named as follows: CMT, central millimetre thickness; F2, area most intensively affected by BRVO-induced oedema; F3, temporal macula; F4, area relatively unaffected by BRVO-induced oedema; F5, nasal macula.
Figure 2
Figure 2
Images obtained from Stratus OCT, Cirrus OCT, and Spectralis OCT showing negligible (▸), moderate ( → ), and severe (formula image) segmentation errors.
Figure 3
Figure 3
Bland–Altman plots comparing mean and difference central millimetre thickness (CMT) values between optical coherence tomography (OCT) devices in control group.
Figure 4
Figure 4
Bland–Altman plots comparing mean and difference central millimetre thickness (CRT) values between optical coherence tomography (OCT) devices in eyes with branch retinal vein occlusion.
Figure 5
Figure 5
Proportion of segmentation errors in eyes with branch retinal vein occlusion. 1: Stratus OCT, 2: Cirrus OCT, 3: Spectralis OCT.
See this image and copyright information in PMC

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