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Review
. 2011 Jan;21(1):39-47.

Primary CNS lymphoma in immunocompetent: a review of literature and our experience from Kashmir

Rumana Makhdoomi  1 , Khursheed Nayil, Ahmad Rayees, Altaf Kirmani, Altaf Ramzan, Muhammad Baba Khalil, Anil Dhar, Syed Besina, Nasima Chanda, Abdul Rashid Lone, Sumaira Qadiri, Muhammad Maqbool
Affiliations
  • PMID: 21294090
Free article
Review

Primary CNS lymphoma in immunocompetent: a review of literature and our experience from Kashmir

Rumana Makhdoomi et al. Turk Neurosurg. 2011 Jan.
Free article

Abstract

Aim: To study the clinicopathological aspects of primary CNS lymphoma in immunocompetent patients.

Material and methods: Sixteen patients with primary CNS lymphoma were analyzed for their clinico-pathological characteristics and followed-up for the treatment and subsequent management in Neurosurgery, and Medical and Radiation Oncology.

Results: The fronto-parietal region was the commonest location of CNS lymphoma; four cases of cerebellar lymphoma were seen. Our patients were relatively young with a mean age of 48 years and an age range of 35-60 years. Females outnumbered males with a ratio of 2.7:1. The commonest presentation was focal neurological-deficits and features of raised intracranial pressure. All the patients histologically had diffuse large B-cell lymphoma. Radiologically, most presented as disc-enhancing lesions. Two patients had multiple lesions. Most of the patients (10) died within a mean of 4.4 months (range 2 weeks-16 months).

Conclusion: Primary CNS lymphoma is seen in immunocompetent patients as well. Relapse is common after treatment and the overall prognosis is unfavorable.

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