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Comparative Study
. 1978 Sep;70(3):348-51.
doi: 10.1093/ajcp/70.3.348.

Serum and lymph-node collagenase in sarcoidosis. Comparison with angiotensin-converting enzyme

Comparative Study

Serum and lymph-node collagenase in sarcoidosis. Comparison with angiotensin-converting enzyme

E Silverstein et al. Am J Clin Pathol. 1978 Sep.

Abstract

Serum collagenase was significantly elevated in stage II, but not stage I sarcoidosis, in contrast to elevation of serum angiotensin-converting enzyme in stages I and II. Neither serum collagenase nor angiotensin-converting enzyme was elevated in active tuberculosis. Elevated serum collagenase and angiotensin-converting enzyme levels were decreased with steroid therapy. Serum collagenase and angiotensin-converting enzyme were significantly correlated but did not vary identically. Collagenase was not elevated in lymph nodes in sarcoidosis, in contrast to marked elevation of angiotensin-converting enzyme. The results suggest that serum angiotensin-converting enzyme is a more sensitive index of sarcoidosis activity than serum collagenase, which may have an ancillary role in assessment of the disease.

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