Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2010 Dec;24(14):1280-8.

Ipilimumab: a promising immunotherapy for melanoma

Jaykumar R Thumar  1 , Harriet M Kluger
Affiliations
  • PMID: 21294471
Free article
Review

Ipilimumab: a promising immunotherapy for melanoma

Jaykumar R Thumar et al. Oncology (Williston Park). 2010 Dec.
Free article

Abstract

Antibody-based targeting of the immune suppressor molecule cytotoxic T-lymphocyte antigen 4 (CTLA-4) with ipilimumab has been studied in metastatic melanoma in a number of clinical trials, including a recent phase III trial. This marks the first randomized clinical trial reporting an overall survival benefit using immune modulation in metastatic melanoma. Along with its therapeutic benefits, ipilimumab presents unique challenges to clinicians; these are related to the monitoring of treatment response and the management of drug-related toxicities. This drug is currently being investigated in various cancers, and its indications are likely to be expanded.

PubMed Disclaimer

Comment in

LinkOut - more resources