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Case Reports
. 2011 Feb 4:9:17.
doi: 10.1186/1477-7819-9-17.

Primary malignant mixed müllerian tumor of the peritoneum a case report with review of the literature

Fisnik Kurshumliu  1 , Helle Rung-Hansen, Vibeke Ravn Skovlund, Lumturije Gashi-Luci, Thomas Horn
Affiliations
Case Reports

Primary malignant mixed müllerian tumor of the peritoneum a case report with review of the literature

Fisnik Kurshumliu et al. World J Surg Oncol. .

Abstract

Malignant mixed Müllerian tumor is a rare malignancy of the genital tract and extremely uncommon in extragenital sites. This report describes a case of malignant mixed Müllerian tumor arising in the lower peritoneum of a 72-year-old female patient. The patient presented with ascites, lower abdominal mass and pleural effusion. The serum level of CA125 was elevated. At operation a diffuse carcinosis associated with tumor mass measuring 20 × 15 × 10 cm in the vesicouterine and Duglas' pouch were found. The uterus and the adnexa were unremarkable. Histopathology revealed a typical malignant mixed Müllerian tumor, heterologous type. The epithelial component was positive for cytokeratin 7 and vimentin whereas the mesenchymal component was positive for Vimentin, S100 and focally for CK7. The histogenesis of this tumor arising from the peritoneum is still speculative. Based on the previous reports and the immunohistochemical analysis of our case, we believe that this is a monoclonal tumor with carcinoma being the "precursor" element. Nevertheless, further molecular and genetic evidence is needed to support such a conclusion.

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Figures

Figure 1
Figure 1
Histological picture showing the admixed carcinoma and spindle cell sarcomatous elements (HE × 200).
Figure 2
Figure 2
Histological picture showing malignant cartilage admixed with sheets of undifferentiated spindle cells (HE × 400).
Figure 3
Figure 3
Immunohistochemical stain with Cytokeratin 7 shows strong immunoreactivity of the undifferentiated epithelial cells (× 400).
Figure 4
Figure 4
Immunohistochemical stain with Cytokeratin 7 shows scattered Cytokeratin 7-positive cells in the mesenchymal component (× 400).
Figure 5
Figure 5
Immunohistochemical stain with Vimentin shows areas with strong immunoreactivity of the epithelial and mesenchymal cells (× 400).
See this image and copyright information in PMC

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