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Review
. 2011 Feb 4:3:5.
doi: 10.1186/1758-3284-3-5.

Dermatofibrosarcoma protuberans with fibrosarcomatous transformation of the head and neck

Nikolaos Angouridakis  1 , Panagiotis Kafas, Waseem Jerjes, Stefanos Triaridis, Tahwinder Upile, Georgios Karkavelas, Angelos Nikolaou
Affiliations
Review

Dermatofibrosarcoma protuberans with fibrosarcomatous transformation of the head and neck

Nikolaos Angouridakis et al. Head Neck Oncol. .

Abstract

Dermatofibrosarcoma protuberans (DFSP) is a rare cutaneous neoplasm associated with a high cure rate. We present a case of aggressive DFSP with fibrosarcomatous areas in the head and neck. A 28-year-old Mediterranean female presented with a 45-day history of rapidly growing cutaneous lesion of the face. Surgical biopsy confirmed the diagnosis of DFSP. Subsequently, the patient underwent wide local surgical resection, followed by reconstruction. Histopathology report revealed fibrosarcomatous transformation and the patient underwent adjuvant radiotherapy. The patient continues to be disease free at the 35-month follow-up.Although DFSP behave as non-aggressive malignancy, surgery with complete removal of the affected area is the intervention of choice. Moreover, adjuvant treatment and follow-up of the patient is essential in order to prevent recurrence.

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Figures

Figure 1
Figure 1
Clinical image showing an infra-auricular lesion (10 × 5 × 4 cm in size).
Figure 2
Figure 2
Computed tomography image showing a parotid mass adherent to overlying skin.
Figure 3
Figure 3
Magnetic resonance image showing a soft tissue mass associated with the parotid gland.
Figure 4
Figure 4
Postoperative image following local excision and reconstruction.
Figure 5
Figure 5
Histopathology image showing dermatofibrosarcoma protuberans. (a) H&E ×10 spindle-shaped tumor cells in a "cartwheel" pattern. (b) H&E ×40 showing increase number of mitosis.
Figure 6
Figure 6
Histopathology image showing immunopositivity to CD34. (a) ×25 showing immunopositivity to CD34. (b) ×40 showing immunopositivity to CD34.
See this image and copyright information in PMC

References

    1. Taylor RW. Sarcomatous tumors resembling in some respects keloids. Arch Dermatol. 1890;8:384–387.
    1. Darrier J, Ferrand M. Dermatofibromes progressifs et recidivants ou fibrosarcomes de la peau. Ann Dermatol Syphiligr (Paris) 1924;5:545–62.
    1. Hoffman E. Uber das knollentreibende fibrosarkom der haut. Dermatol Zischr. 1925;43:1–28. doi: 10.1159/000250699. - DOI
    1. Lemm D, Mügge LO, Mentzel T, Höffken K. Current treatment options in dermatofibrosarcoma protuberans. J Cancer Res Clin Oncol. 2009;135(5):653–65. doi: 10.1007/s00432-009-0550-3. - DOI - PubMed
    1. Laskin WB. Dermatofibrosarcoma protuberans. CA Cancer J Clin. 1992;42(2):116–25. doi: 10.3322/canjclin.42.2.116. - DOI - PubMed

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