Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1990 Jan;2(1):9-12.
doi: 10.1016/1043-4666(90)90037-t.

Cloning and expression of a cDNA for the human homolog of mouse T cell and mast cell growth factor P40

J C Renauld  1 , A Goethals, F Houssiau, E Van Roost, J Van Snick
Affiliations

Cloning and expression of a cDNA for the human homolog of mouse T cell and mast cell growth factor P40

J C Renauld et al. Cytokine. 1990 Jan.

Abstract

A cDNA encoding the human homolog of mouse T-cell and mast cell growth factor P40 was derived from peripheral blood mononuclear cells (PBMC) stimulated with phytohemagglutinin and phorbol myristate acetate. Sequence analysis of the cDNA predicted a precursor protein of 144 amino acids including a signal peptide of 18 residues, a structure identical with that of mouse P40. The homology between the mouse and human proteins is 55% with a perfect conservation of the 10 cysteine residues present in the mature polypeptide. Expression of the cDNA for human P40 in a baculovirus vector yielded a protein capable of enhancing in vitro survival of human T cell lines.

PubMed Disclaimer

Publication types

LinkOut - more resources