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Comment
. 2011 Feb 4;8(2):122-4.
doi: 10.1016/j.stem.2011.01.006.

A comprehensive transcriptional landscape of human hematopoiesis

Barbara L Kee  1
Affiliations
Free article
Comment

A comprehensive transcriptional landscape of human hematopoiesis

Barbara L Kee. Cell Stem Cell. .
Free article

Abstract

Recently in Cell, Novershtern et al. (2011) reported a comprehensive transcriptome analysis of human hematopoiesis, combined with sophisticated bioinformatics analysis and high-throughput DNA binding data for multiple transcription factors. The resulting map of regulatory interactions controlling stem cell differentiation provides a valuable resource for identification of novel hematopoietic regulators.

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  • Densely interconnected transcriptional circuits control cell states in human hematopoiesis.
    Novershtern N, Subramanian A, Lawton LN, Mak RH, Haining WN, McConkey ME, Habib N, Yosef N, Chang CY, Shay T, Frampton GM, Drake AC, Leskov I, Nilsson B, Preffer F, Dombkowski D, Evans JW, Liefeld T, Smutko JS, Chen J, Friedman N, Young RA, Golub TR, Regev A, Ebert BL. Novershtern N, et al. Cell. 2011 Jan 21;144(2):296-309. doi: 10.1016/j.cell.2011.01.004. Cell. 2011. PMID: 21241896 Free PMC article.

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