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Comment
. 2011 Feb 4;8(2):126-7.
doi: 10.1016/j.stem.2011.01.004.

A twist of cell fate

Thea D Tlsty  1
Affiliations
Free article
Comment

A twist of cell fate

Thea D Tlsty. Cell Stem Cell. .
Free article

Abstract

Individuals carrying deleterious BRCA1 mutations typically develop basal-like rather than luminal breast cancers. In this issue of Cell Stem Cell, Proia et al. (2011) study breast tissue from women with heterozygous BRCA1 mutations and identify molecular mechanisms that regulate mammary progenitor cell differentiation and bias toward subsequent basal-like tumor formation.

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