Comparative Study
doi: 10.1038/347645a0.
Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
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- PMID: 2129546
- DOI: 10.1038/347645a0
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Comparative Study
Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
Nature.
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Abstract
We have cloned a member of the steroid hormone receptor superfamily of ligand-activated transcription factors. The receptor homologue is activated by a diverse class of rodent hepatocarcinogens that causes proliferation of peroxisomes. Identification of a peroxisome proliferator-activated receptor should help elucidate the mechanism of the hypolipidaemic effect of these hepatocarcinogens and aid evaluation of their potential carcinogenic risk to man.
Comment in
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Drug metabolism. Growth signal pathways.Nature. 1990 Oct 25;347(6295):709-10. doi: 10.1038/347709a0. Nature. 1990. PMID: 2172828 No abstract available.
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