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Comparative Study
. 1990 Oct 18;347(6294):645-50.
doi: 10.1038/347645a0.

Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators

I Issemann  1 , S Green
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Comparative Study

Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators

I Issemann et al. Nature. .

Abstract

We have cloned a member of the steroid hormone receptor superfamily of ligand-activated transcription factors. The receptor homologue is activated by a diverse class of rodent hepatocarcinogens that causes proliferation of peroxisomes. Identification of a peroxisome proliferator-activated receptor should help elucidate the mechanism of the hypolipidaemic effect of these hepatocarcinogens and aid evaluation of their potential carcinogenic risk to man.

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