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Comment
. 2011 Feb 4;144(3):321-3.
doi: 10.1016/j.cell.2011.01.025.

A versatile sugar transferase makes the cut

John A Hanover  1
Affiliations
Comment

A versatile sugar transferase makes the cut

John A Hanover. Cell. .

Abstract

The nutrient sensor O-GlcNAc transferase modifies proteins with the O-GlcNAc moiety. In this issue, Capotosti et al. (2011) reveal that O-GlcNAc transferase not only glycosylates the cell-cycle regulator host cell factor 1 but activates it through proteolytic cleavage, providing a surprising link between metabolism and epigenetic regulation of the cell cycle.

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Figures

Figure 1.
Figure 1.. OGT GlcNAcylates and Cleaves HCF-1 for Cell-Cycle Progression
O-GlcNAc transferase (OGT) couples the nutrient-dependent synthesis of UDP-GlcNAc to the O-GlcNAcylation of numerous targets including the cell-cycle regulator host cell factor 1 (HCF-1). OGT is also necessary and sufficient for proteolysis of the HCF-1PRO domain; together O-GlcNAcylation and cleavage of HCF-1 promote changes in chromatin organization that are required for progression through G1-S and M phases of the cell cycle. OGT and HCF-1 are tethered together in a tight complex and share a number of known binding partners and targets, participating in chromatin remodeling and cell-cycle regulation to influence stem cell fate, development, and disease-related processes including immunity, cancer, diabetes, and neurodegeneration.
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References

    1. Butkinaree C, Park K, and Hart GW (2010). Biochim. Biophys. Acta 1800, 96–106. - PMC - PubMed
    1. Capotosti F, Guernier S, Lammers F, Waridel P, Cai Y, Jin J, Conaway JW, and Herr W (2011). Cell 144, this issue, 376–388. - PubMed
    1. Goto H, Motomura S, Wilson AC, Freiman RN, Nakabeppu Y, Fukushima K, Fujishima M, Herr W, and Nishimoto T (1997). Genes Dev 11, 726–737. - PubMed
    1. Hanover JA, Krause MW, and Love DC (2010). Biochim. Biophys. Acta 1800, 80–95. - PMC - PubMed
    1. Kristie TM, Liang Y, and Vogel JL (2010). Biochim. Biophys. Acta 1799, 257–265. - PMC - PubMed

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