Getting cells and tissues into shape
- PMID: 21295695
- DOI: 10.1016/j.cell.2011.01.022
Getting cells and tissues into shape
Abstract
Cells of all shapes and sizes are able to calculate the location of their middles in order to divide into two during mitosis. Minc et al. (2011) and Gibson et al. (2011) now show that simple mechanical models accurately predict cleavage-plane positioning, and that geometrical interactions between neighboring cells are sufficient to generate ordered patterns of mitosis in growing epithelia.
Copyright © 2011 Elsevier Inc. All rights reserved.
Comment on
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Influence of cell geometry on division-plane positioning.Cell. 2011 Feb 4;144(3):414-26. doi: 10.1016/j.cell.2011.01.016. Cell. 2011. PMID: 21295701 Free PMC article.
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Control of the mitotic cleavage plane by local epithelial topology.Cell. 2011 Feb 4;144(3):427-38. doi: 10.1016/j.cell.2010.12.035. Cell. 2011. PMID: 21295702 Free PMC article.
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