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Review
. 2011 Mar;31(1):139-59.
doi: 10.1016/j.cll.2010.10.009.

Comparative hemostasis: animal models and new hemostasis tests

Marjory B Brooks  1 , Tracy Stokol, James L Catalfamo
Affiliations
Review

Comparative hemostasis: animal models and new hemostasis tests

Marjory B Brooks et al. Clin Lab Med. 2011 Mar.

Abstract

This article provides an overview of animal model systems to include their strengths and limitations in the study of hemostasis. Specific examples of spontaneous and engineered animal models are described in the context of cell-based hemostasis. The article concludes with a review of the comparative aspects of 3 laboratory assays of cell-based hemostasis: thromboelastography, thrombin generation, and flow cytometric assessment of platelet activation.

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