Comparative hemostasis: animal models and new hemostasis tests
- PMID: 21295727
- DOI: 10.1016/j.cll.2010.10.009
Comparative hemostasis: animal models and new hemostasis tests
Abstract
This article provides an overview of animal model systems to include their strengths and limitations in the study of hemostasis. Specific examples of spontaneous and engineered animal models are described in the context of cell-based hemostasis. The article concludes with a review of the comparative aspects of 3 laboratory assays of cell-based hemostasis: thromboelastography, thrombin generation, and flow cytometric assessment of platelet activation.
Copyright © 2011 Elsevier Inc. All rights reserved.
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