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. 2011 Jan 27;7(1):e1002002.
doi: 10.1371/journal.pgen.1002002.

Rnf12--a jack of all trades in X inactivation?

Edda G Schulz  1 , Elphège P Nora, Edith Heard
Affiliations

Rnf12--a jack of all trades in X inactivation?

Edda G Schulz et al. PLoS Genet. .
No abstract available

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. The X chromosome inactivation network.
(A) Xist expression is controlled by counteracting activators (red) and repressors (blue). Stem cell factors (blue ovals) might repress Xist directly or indirectly via activating the repressive transcript Tsix or repressing the activator Rnf12. Rnf12 is the only known activator, and may function by targeting the Xist promoter directly and/or by inducing degradation of an unknown Xist repressor (blue squares). The existence of additional X-linked activators (red triangles) and long-range control elements such as Xpr, Xce, Xite, and others (red box) has been suggested . (B) The time window when XCI can be initiated (grey) could be controlled by the down-regulation of Xist repressors such as stem cell factors (blue) and up-regulation of Xist activators like Rnf12 (red). (C) Different cell lines might require Rnf12 (ESC line B) or not (ESC line A), depending on the expression kinetics of other X-linked activators (dotted red line).
See this image and copyright information in PMC

References

    1. Chow J, Heard E. X inactivation and the complexities of silencing a sex chromosome. Curr Opin Cell Biol. 2009;21:359–366. - PubMed
    1. Jonkers I, Barakat TS, Achame EM, Monkhorst K, Kenter A, et al. RNF12 is an X-Encoded dose-dependent activator of X chromosome inactivation. Cell. 2009;139:999–1011. - PubMed
    1. Barakat TS, Gunhanlar N, Pardo CG, Achame EM, Ghazvini M, et al. RNF12 activates Xist and is essential for X chromosome inactivation. PLoS Genet. 2011;7:e1002001. doi: 10.1371/journal.pgen.1002001. - DOI - PMC - PubMed
    1. Shin J, Bossenz M, Chung Y, Ma H, Byron M, et al. Maternal Rnf12/RLIM is required for imprinted X-chromosome inactivation in mice. Nature. 2010;467:977–981. - PMC - PubMed
    1. Navarro P, Chambers I, Karwacki-Neisius V, Chureau C, Morey C, et al. Molecular coupling of Xist regulation and pluripotency. Science. 2008;321:1693–1695. - PubMed