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Review
. 2011 May 15;317(9):1293-300.
doi: 10.1016/j.yexcr.2011.01.024. Epub 2011 Feb 4.

Anti-cytokine therapies for psoriasis

Kristine E Nograles  1 , James G Krueger
Affiliations
Review

Anti-cytokine therapies for psoriasis

Kristine E Nograles et al. Exp Cell Res. .

Abstract

Current approaches for the treatment of psoriasis with anti-cytokine therapies involve the blockade of TNF-α, or the p40 sub-unit of IL-12 and IL-23. However, the field is currently evolving to test more selective antagonists, such as anti-IL-23p19, IL-17 and other inflammatory cytokines. Here we discuss our current understanding of dendritic cell and T cell subsets that are relevant in psoriasis, and the pharmacologic strategies that temper their activity in this disease.

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