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Randomized Controlled Trial
. 2011 Apr;95(5):1568-73.
doi: 10.1016/j.fertnstert.2011.01.027.

Randomized trial of leuprolide versus continuous oral contraceptives in the treatment of endometriosis-associated pelvic pain

David S Guzick  1 , Li-Shan Huang, Betsy A Broadman, Maureen Nealon, Mark D Hornstein
Affiliations
Randomized Controlled Trial

Randomized trial of leuprolide versus continuous oral contraceptives in the treatment of endometriosis-associated pelvic pain

David S Guzick et al. Fertil Steril. 2011 Apr.

Abstract

Objective: To compare the efficacy of leuprolide and continuous oral contraceptives in the treatment of endometriosis-associated pain.

Design: Prospective, randomized, double-blind controlled trial.

Setting: Academic medical centers in Rochester, New York, and Boston, Massachusetts.

Patient(s): Forty-seven women with endometriosis-associated pelvic pain.

Intervention(s): Forty-eight weeks of either depot leuprolide, 11.25 mg IM every 12 weeks with hormonal add-back using norethindrone acetate 5 mg orally, daily; or a generic monophasic oral contraceptive (1 mg norethindrone + 35 mg ethinyl estradiol) given daily.

Main outcome measure(s): Biberoglu and Behrman (B&B) pain scores, numerical rating scores (NRS), Beck Depression Inventory (BDI), and Index of Sexual Satisfaction (ISS).

Result(s): Based on enrollment of 47 women randomized to continuous oral contraceptives and to leuprolide, there were statistically significant declines in B&B, NRS, and BDI scores from baseline in both groups. There were no significant differences, however, in the extent of reduction in these measures between the groups.

Conclusion(s): Leuprolide and continuous oral contraceptives appear to be equally effective in the treatment of endometriosis-associated pelvic pain.

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Figures

FIGURE 1
FIGURE 1
Comparison of trends between leuprolide and oral contraceptive groups in pain and quality-of-life assessments. Mean values with standard error bars are shown at each time of assessment.
See this image and copyright information in PMC

References

    1. Walker EA, Katon WJ, Jemelka RP. The prevalence of chronic pelvic pain and irritable bowel syndrome in two university clinics. J Psychosom Obstet Gynecol. 1991;12(Suppl):65–75.
    1. Jamieson DJ, Steege JF. The prevalence of dysmenor-rhea, dyspareunia, pelvic pain, and irritable bowel syndrome in primary care practices. Obstet Gynecol. 1996;87:55–8. - PubMed
    1. Milburn A, Reiter RC, Rhomberg AT. Multi-disciplinary approach to chronic pelvic pain. Obstet Gynecol Clin North Am. 1993;20:643–61. - PubMed
    1. Howard FM. Laparoscopic evaluation and treatment of women with chronic pelvic pain. J Am Assoc Gynecol Laparosc. 1994;1:325–31. - PubMed
    1. Candiani GB, Fedele L, Vercellini P, Bianchi S, Di Nola G. Presacral neurectomy for the treatment of pelvic pain associated with endometriosis: a controlled study. Am J Obstet Gynecol. 1992;167(1):100–3. - PubMed

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