doi: 10.1007/BF01843983.
Genetic basis for unresponsiveness to lipopolysaccharide in C57BL/10Cr mice
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- PMID: 21302052
- DOI: 10.1007/BF01843983
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Genetic basis for unresponsiveness to lipopolysaccharide in C57BL/10Cr mice
Immunogenetics.
1978 Dec.
Abstract
The unresponsiveness to LPS detected in C57BL/10Cr mice is inherited as a recessive trait and is determined by an autosomal gene linked to theMup-1 locus on chromosome 4. Since no complementation for LPS responsiveness was observed in F(1) hybrid mice between C3H/HeJ and C57BL/10Cr, we conclude that C57BL/10Cr mice carry a defective allele at the sameLps locus, previously identified by the mutation detected in the C3H/HeJ strain.
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