Therapy: Spleen tyrosine kinase inhibitors--novel therapies for RA?
- PMID: 21304505
- DOI: 10.1038/nrrheum.2011.8
Therapy: Spleen tyrosine kinase inhibitors--novel therapies for RA?
Abstract
In patients with active rheumatoid arthritis despite therapy with DMARDS, treatment with a spleen tyrosine kinase inhibitor has achieved similar response rates to those achieved in clinical trials of other drugs, including biologic agents. Where might these agents fit in the current armamentarium against this disease?
Comment on
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An oral spleen tyrosine kinase (Syk) inhibitor for rheumatoid arthritis.N Engl J Med. 2010 Sep 30;363(14):1303-12. doi: 10.1056/NEJMoa1000500. Epub 2010 Sep 22. N Engl J Med. 2010. PMID: 20879879 Clinical Trial.
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