Pharmacogenetics: Anti-TNF therapy in RA--towards personalized medicine?
- PMID: 21304506
- DOI: 10.1038/nrrheum.2011.13
Pharmacogenetics: Anti-TNF therapy in RA--towards personalized medicine?
Abstract
A substantial proportion of patients with rheumatoid arthritis do not respond to tumor necrosis factor blocking therapy. Results of a large genome-wide association study demonstrate evidence of novel genetic factors that determine response to treatment, which could provide a basis for individualizing therapy.
Comment on
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Genome-wide association study of genetic predictors of anti-tumor necrosis factor treatment efficacy in rheumatoid arthritis identifies associations with polymorphisms at seven loci.Arthritis Rheum. 2011 Mar;63(3):645-53. doi: 10.1002/art.30130. Arthritis Rheum. 2011. PMID: 21061259 Free PMC article.
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