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. 2011 Jun;19(6):667-71.
doi: 10.1038/ejhg.2010.257. Epub 2011 Feb 9.

Identification of regions of positive selection using Shared Genomic Segment analysis

Zheng Cai  1 , Nicola J Camp, Lisa Cannon-Albright, Alun Thomas
Affiliations

Identification of regions of positive selection using Shared Genomic Segment analysis

Zheng Cai et al. Eur J Hum Genet. 2011 Jun.

Abstract

We applied a shared genomic segment (SGS) analysis, incorporating an error model, to identify complete, or near complete, selective sweeps in the HapMap phase II data sets. This method is based on detecting heterozygous sharing across all individuals within a population, to identify regions of sharing with at least one allele in common. We identified multiple interesting regions, many of which are concordant with positive selection regions detected by previous population genetic tests. Others are suggested to be novel regions. Our finding illustrates the utility of SGS as a method for identifying regions of selection, and some of these regions have been proposed to be candidate regions for harboring disease genes.

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Figures

Figure 1
Figure 1
SGS observation in three HapMap populations. Y-axis is Ōi (45). (a) HapMap CEU data set. (b) HapMap ASN data set. (c) HapMap YRI data set. The color reproduction of this figure is available on the html full text version of the manuscript.
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