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. 2011 Mar 25;74(3):374-7.
doi: 10.1021/np100736y. Epub 2011 Feb 9.

Inhibitors of the oncogenic transcription factor AP-1 from Podocarpus latifolius

Krishna P Devkota  1 , Ranjala Ratnayake, Nancy H Colburn, Jennifer A Wilson, Curtis J Henrich, James B McMahon, John A Beutler
Affiliations

Inhibitors of the oncogenic transcription factor AP-1 from Podocarpus latifolius

Krishna P Devkota et al. J Nat Prod. .

Abstract

An activator protein-1 (AP-1) based bioassay-guided phytochemical investigation on Podocarpus latifolius led to the isolation of three new sempervirol-type diterpenes, cycloinumakiol (1), inumakal (2), and inumakoic acid (3), along with three known norditerpenes (4-6). Compounds 4 and 6 were responsible for the observed bioactivity.

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Figures

Figure 1
Figure 1
Key ROESY interactions in compound 1
See this image and copyright information in PMC

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