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. 2010 May;12(3):165-73.
doi: 10.1007/s11908-010-0099-y.

Drug-Resistant Malaria: The Era of ACT

Jessica T Lin  1 , Jonathan J Juliano, Chansuda Wongsrichanalai
Affiliations

Drug-Resistant Malaria: The Era of ACT

Jessica T Lin et al. Curr Infect Dis Rep. 2010 May.

Abstract

As drug-resistant falciparum malaria has continued to evolve and spread worldwide, artemisinin-based combination therapies (ACT) have become the centerpiece of global malaria control over the past decade. This review discusses how advances in antimalarial drug resistance monitoring and rational use of the array of ACTs now available can maximize the impact of this highly efficacious therapy, even as resistance to artemisinins is emerging in Southeast Asia.

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Conflict of interest statement

Disclosure: No potential conflict of interest relevant to this article was reported.

Figures

Fig. 1
Fig. 1
Number of countries adopting ACTs as first-line therapy by year, disaggregated by specific ACT drug. Each value marked indicates the cumulative number of countries having adopted the ACT by that year. The statistics shown are for policy adoption and do not necessarily represent policy implementation. AL artemether-lumefantrine; ASAQ artesunate-amodiaquine; AS-SP artesunate-sulfadoxine-pyrimethamine; ASMQ artesunate-mefloquine; DHA-PQ dihydroartemisinin-piperaquine. (Data from World Health Organization [–20])
See this image and copyright information in PMC

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