Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011 Mar;13(3):203-4.
doi: 10.1097/GIM.0b013e31820d5e87.

Unifying cancer genetics

Sharon E Plon  1
Affiliations

Unifying cancer genetics

Sharon E Plon. Genet Med. 2011 Mar.
No abstract available

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Schematic diagram of the Ras signaling pathway which is disrupted in juvenile myelomonocytic leukemia (JMML). Inherited susceptibility to JMML genes are depicted in light blue. Genes with somatic mutation in JMML are depicted in pink. The impact of Ras signaling on ASXL1 function is not clear. RTK, receptor tyrosine kinase. Modified with permission from Curr Opin Genet Dev.
See this image and copyright information in PMC

References

    1. Rushlow D, Piovesan B, Zhang K, et al. Detection of mosaic RB1 mutations in families with retinoblastoma. Hum Mutat. 2009;30:842–851. - PubMed
    1. Cancer Genome Atlas Research Network Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature. 455:1061–1068. 008. - PMC - PubMed
    1. Armengol C, Cairo S, Fabre M, Buendia MA. Wnt signaling and hepatocarcinogenesis: The hepatoblastoma model. Int J Biochem Cell Biol. 2009 - PubMed
    1. Lopez-Terrada D, Gunaratne PH, Adesina AM, et al. Histologic subtypes of hepatoblastoma are characterized by differential canonical Wnt and Notch pathway activation in DLK+ precursors. Hum Pathol. 2009;40:783–794. - PubMed
    1. Aretz S, Koch A, Uhlhaas S, et al. Should children at risk for familial adenomatous polyposis be screened for hepatoblastoma and children with apparently sporadic hepatoblastoma be screened for APC germline mutations? Pediatr Blood Cancer. 2006;47:811–818. - PubMed

Publication types

Substances