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. 1978 Oct;64(2):223-7.
doi: 10.1111/j.1476-5381.1978.tb17293.x.

Adrenocorticotrophic hormone fragments mimic the effect of morphine in vitro

G J Plomp, J M Van Ree

Adrenocorticotrophic hormone fragments mimic the effect of morphine in vitro

G J Plomp et al. Br J Pharmacol. 1978 Oct.

Abstract

1 Fragments of the N terminal part of adrenocorticotrophic hormone (ACTH) inhibited the electrically evoked contractions of the mouse vas deferens. This inhibition could be antagonized by naloxone. 2 The same fragments displaced radiolabelled morphine from morphine antiserum. 3 Structure-activity relationship studies showed that in both assay systems the active core is located within the sequence ACTH 7--10. 4 It is postulated that the Trp9 residue and the peptide bond between Trp9 and Gly10 are particularly important for interaction of ACTH fragments with morphine receptors.

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References

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