Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011 Apr;90(4):433-8.
doi: 10.1177/0022034510387795. Epub 2011 Feb 11.

ONJ in two dental practice-based research network regions

J L Fellows  1 , D B Rindal, A Barasch, C M Gullion, W Rush, D J Pihlstrom, J Richman; DPBRN Collaborative Group
Collaborators, Affiliations

ONJ in two dental practice-based research network regions

J L Fellows et al. J Dent Res. 2011 Apr.

Abstract

The incidence of osteonecrosis of the jaw (ONJ) in the population is low, but specifics are unknown. Potential risk factors include bisphosphonate treatment, steroid treatment, osteoporosis, and head/neck radiation. This Dental Practice-Based Research Network study estimated ONJ incidence and odds ratios from bisphosphonate exposure and other risk factors using a key word search and manual chart reviews of electronic records for adults aged ≥ 35 yrs enrolled during 1995-2006 in two large health-care organizations. We found 16 ONJ cases among 572,606 cohort members; seven additional cases were identified through dental plan resources. Among 23 cases (0.63 per 100,000 patient years), 20 (87%) had at least one risk factor, and six (26%) had received oral bisphosphonates. Patients with oral bisphosphonates were 15.5 (CI, 6.0-38.7) more likely to have ONJ than non-exposed patients; however, the sparse number of ONJ cases limits firm conclusions and suggests that the absolute risks for ONJ from oral bisphosphonates is low.

PubMed Disclaimer

Republished in

Comment in

References

    1. American Association of Oral and Maxillofacial Surgeons (2007). Position paper on bisphosphonate-related osteonecrosis of the jaw. J Oral Maxillofac Surg 65:369-376 - PubMed
    1. Bilezikian JP. (2006). Osteonecrosis of the jaw–do bisphosphonates pose a risk? N Engl J Med 355:2278-2281 - PubMed
    1. Cartsos VM, Zhu S, Zavras AI. (2008). Bisphosphonate use and the risk of adverse jaw outcomes: a medical claims study of 714,217 people. J Am Dent Assoc 139:23-30 - PubMed
    1. Edwards BJ, Gounder M, McKoy JM, Boyd I, Farrugia M, Migliorati C, et al. (2008). Pharmacovigilance and reporting oversight in US FDA fast-track process: bisphosphonates and osteonecrosis of the jaw. Lancet Oncol 9:1166-1172 - PubMed
    1. Estefania-Fresco R, Ponte-Fernández N, Aguirre-Urizar JM. (2006). Bisphosphonates and oral pathology II. Osteonecrosis of the jaws: review of the literature before 2005. Med Oral Pathol Oral Cir Bucal 11:E456-E461 - PubMed

Publication types

MeSH terms