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. 2011 Feb 11;16(2):1508-18.
doi: 10.3390/molecules16021508.

Polycationic glycosides

Robert Engel  1 , Ishrat Ghani, Diego Montenegro, Marie Thomas, Barbara Klaritch-Vrana, Alejandra Castaño, Laura Friedman, Jay Leb, Leah Rothman, Heidi Lee, Craig Capodiferro, Daniel Ambinder, Eva Cere, Christopher Awad, Faiza Sheikh, Jaimelee Rizzo, Lisa-Marie Nesbitt, Erika Testani, Karin Melkonian
Affiliations

Polycationic glycosides

Robert Engel et al. Molecules. .

Abstract

Cationic lipids have long been known to serve as antibacterial and antifungal agents. Prior efforts with attachment of cationic lipids to carbohydrate-based surfaces have suggested the possibility that carbohydrate-attached cationic lipids might serve as antibacterial and antifungal pharmaceutical agents. Toward the understanding of this possibility, we have synthesized several series of cationic lipids attached to a variety of glycosides with the intent of generating antimicrobial agents that would meet the requirement for serving as a pharmaceutical agent, specifically that the agent be effective at a very low concentration as well as being biodegradable within the organism being treated. The initial results of our approach to this goal are presented.

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Figures

Scheme 1
Scheme 1
Reaction for preparation of polycationic glycosides.
See this image and copyright information in PMC

References

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