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Review
. 2011 Jun;31(3):430-5.
doi: 10.1007/s10875-010-9501-7. Epub 2011 Feb 12.

Aging affects human B cell responses

Daniela Frasca  1 , Bonnie B Blomberg
Affiliations
Review

Aging affects human B cell responses

Daniela Frasca et al. J Clin Immunol. 2011 Jun.

Abstract

Aging represents a complex remodeling in which both innate and adaptive immunities deteriorate. Age-related changes in humoral immunity are responsible for the reduced vaccine responses observed in elderly individuals. Although T cell alterations play a significant role in age-related humoral immune changes, alterations in B cells also occur. We here provide an overview of age-related changes in B cell markers and functions. Our studies have shown that intrinsic changes in B cells with age contribute to reduced antibody responses such as those to the influenza vaccine.

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