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Comment
. 2011 Feb 17;9(2):83-4.
doi: 10.1016/j.chom.2011.01.012.

Peaceful mutualism in the gut: revealing key commensal bacteria for the creation and maintenance of immunological homeostasis

Jun Kunisawa  1 , Hiroshi Kiyono
Affiliations
Free article
Comment

Peaceful mutualism in the gut: revealing key commensal bacteria for the creation and maintenance of immunological homeostasis

Jun Kunisawa et al. Cell Host Microbe. .
Free article

Abstract

Quantitative and qualitative aspects of commensal bacteria determine the active and quiescent status of host immunity. In a recent Science paper, Atarashi et al. (2011) identify Clostridium clusters IV and XIVa as indigenous commensal bacteria that induce regulatory T cells for the creation and maintenance of immunological homeostasis.

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  • Induction of colonic regulatory T cells by indigenous Clostridium species.
    Atarashi K, Tanoue T, Shima T, Imaoka A, Kuwahara T, Momose Y, Cheng G, Yamasaki S, Saito T, Ohba Y, Taniguchi T, Takeda K, Hori S, Ivanov II, Umesaki Y, Itoh K, Honda K. Atarashi K, et al. Science. 2011 Jan 21;331(6015):337-41. doi: 10.1126/science.1198469. Epub 2010 Dec 23. Science. 2011. PMID: 21205640 Free PMC article.

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