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. 2011 Mar;16(2):144-54.
doi: 10.3109/1354750X.2010.536257.

Is 24h nicotine equivalents a surrogate for smoke exposure based on its relationship with other biomarkers of exposure?

Jingzhu Wang  1 , Qiwei Liang, Paul Mendes, Mohamadi Sarkar
Affiliations

Is 24h nicotine equivalents a surrogate for smoke exposure based on its relationship with other biomarkers of exposure?

Jingzhu Wang et al. Biomarkers. 2011 Mar.

Abstract

Nicotine and its 5 major metabolites (Nicotine equivalents, NE) may serve as a surrogate biomarker for smoke exposure.

Objective: To investigate the relationship between nicotine equivalents (NE) and biomarkers of exposure (BOE) to cigarette smoke.

Methods: Data from nine controlled studies in 916 adult smokers were used. BOEs to nicotine, NNK, pyrene, acrolein, benzene, 1,3-butadiene and CO were used.

Results: Among all the factors investigated (NE, cigarette type, age, gender, BMI and study), NE was the most statistically significant factor for all biomarker relationships. Weak to moderate relationships (0.32 ≤ R(2) ≤ 0.65) were found between NE and the BOEs.

Conclusions: Based on the relationships with BOEs, NE may be considered as a surrogate biomarker of total cigarette smoke exposure.

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