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Review
. 2011 Apr 19;183(7):E420-2.
doi: 10.1503/cmaj.100313. Epub 2011 Feb 14.

Oseltamivir-resistant pandemic H1N1 influenza

Duncan Webster  1 , Yan Li, Nathalie Bastien, Richard Garceau, Todd F Hatchette
Affiliations
Review

Oseltamivir-resistant pandemic H1N1 influenza

Duncan Webster et al. CMAJ. .
No abstract available

PubMed Disclaimer

Figures

Figure 1:
Figure 1:
(A) The action of neuraminidase in the continued replication of virions in the setting of influenza infection. The replication is blocked by neuraminidase inhibitors (B), which prevent virions from being released from the surface of infected cells. (C) Binding of oseltamivir and zanamivir to the neuraminidase-active sites. (D) With mutation, a conformational change at the binding site prevents binding of oseltamivir but permits binding of zanamivir. (Images obtained from N Engl J Med 2005;353:1363–73 and N Engl J Med 2005;353:2633–6 and reprinted with permission of the publisher. Copyright © 2005 Massachusetts Medical Society. All rights reserved.)
See this image and copyright information in PMC

References

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