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. 2011 Feb 16;30(4):634-5.
doi: 10.1038/emboj.2011.12.

AMPK and autophagy get connected

D Grahame Hardie  1
Affiliations

AMPK and autophagy get connected

D Grahame Hardie. EMBO J. .

Erratum in

  • EMBO J. 2011;30(12):2511

Abstract

Niida et al provide the first conclusive evidence that the DNA damage checkpoint kinases Chk1 and Chk2 are bona fide tumour suppressors, also giving insight into the unique and redundant functions of these two factors in vivo.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Figure 1
Figure 1
Domain structure of ULK1 with locations of phosphorylation sites identified by the Shaw and Guan groups (top); and summary of signalling pathways impacting on autophagy or cell growth (bottom). Numbering of ULK1 residues is based on the human sequence; most of the putative phosphorylation sites are conserved across mammals but, because of difficulties in making alignments of the poorly conserved S/T-rich domain, it is not easy to assess which are conserved in lower eukaryotes, including yeast.
See this image and copyright information in PMC

References

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