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Review
. 2010 Sep-Oct;1(2):81-4.
doi: 10.4161/trns.1.2.12375.

Yin Yang 1: a multifaceted protein beyond a transcription factor

Zhiyong Deng  1 , Paul Cao, Mei Mei Wan, Guangchao Sui
Affiliations
Review

Yin Yang 1: a multifaceted protein beyond a transcription factor

Zhiyong Deng et al. Transcription. 2010 Sep-Oct.

Abstract

As a transcription factor, Yin Yang 1 (YY1) regulates the transcription of a dazzling list of genes and the number of its targets still mounts. Recent studies revealed that YY1 possesses functions independent of its DNA binding activity and its regulatory role in tumorigenesis has started to emerge.

Keywords: Yin Yang 1; androgen receptor; coactivator; prostate cancer; protein modification; transcription factor.

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Figures

Figure 1
Figure 1
Schematic models of YY1 regulated gene expression. YY1 can act as transcription activator (A), repressor (B) and coactivator (C, with the PSA promoter as an example). Other coactivators (designated as CoAc1 and CoAc2) can be recruited by YY1 to facilitate AR-mediated PSA transcription.
See this image and copyright information in PMC

References

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